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ADHD RESEARCH UPDATE - Vol. 11, June, 1998
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In this issue...

  • What do we know about medication treatment for adults?

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  • What do teachers know about ADHD?

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  • Self-perceptions and social relations in boys with ADHD

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  • Does Ritalin in the late afternoon create insomnia?

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  • What is Conduct Disorder?

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    - Reader Questions -

    "Will my child be "labeled" if I tell his teacher that he has ADHD?"

    "I'm trying to encourage good behavior in my child at school this year by promising him a reward on the weekend if he has a good week at school. After only 2 weeks, though, it is clear that this does not seem to be working. Any suggestions?"
     

    * MEDICATION TREATMENT FOR ADULTS WITH ADHD *

    The Journal of Clinical Psychiatry recently published a special issue on Attention Deficit Disorder (Volume 69, 1998). One very nice review article in this issue summarizes what is known about the medication treatment of ADD/ADHD in adults. The article is written by Dr. Paul Wender, who has been one of the leaders in the study of ADD in adult populations.

    Dr. Wender begins by summarizing the guidelines he uses for establishing the diagnosis of ADHD in adults. First, as required by DSM-IV, ADHD symptoms must have been present during childhood. Next, he looks for the presence of certain characteristics in adulthood that he feels are how ADHD is manifested in adults. These characteristics include: motor hyperactivity, attention deficits, affective lability (i.e. moodiness), hot temper, emotional over reactivity, disorganization and an inability to complete tasks, and impulsivity.

    (You will note that several of these characteristics have to do with emotional factors rather than primary ADHD symptoms per se. Actually, there are many mental health professionals who feel that the current DSM-IV diagnostic criteria (for a review of these click here are not appropriate to use with adults because they are really more applicable to how children behave. There is good work being done now to try and devise a more appropriate set of diagnostic criteria in adults. Dr. Wender was the person who first got this important work started.)

    In Dr. Wender's treatment research, he has evaluated the response of over 300 adults diagnosed with ADHD using his diagnostic criteria. These studies all used placebo-controlled, double blind procedures that are so essential for realistically assessing the effectiveness of medication on ADHD symptoms. (Remember, in this type of study a subjects' response to medication is compared to how they respond to a placebo. If the medication is really helpful, you would see greater improvement than that produced by a placebo alone.)

    As with children, the medication studied most frequently (i.e. 176 patients) has been methylphenidate (i.e. the generic name for Ritalin.) In Dr. Wender's research about 60% of adults treated with methylphenidate showed "moderate to marked" improvement compared with only 10% of patients who showed comparable improvement on placebo. Comparable response rates were reported for adults who received Pemoline (i.e. the generic version of Cylert) and Dexedrine.

    It is interesting to note that although these results suggest that stimulant medications that are helpful to children with ADHD are also helpful to adults, the response rate reported for adults is substantially lower than has been found for children. For children, the rate of positive response to stimulant medication ion has been consistently found to be approximately 80%, with some authors reporting that over 90% of children with ADHD will derive substantial benefit from medication if a sufficient number of alternatives are carefully tried. In terms of the clinical effects of these medications in adults, Dr. Wender reports the following:
     

  • fidgeting and restlessness decrease;

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  • patients report an increased ability to concentrate and feel that they have greater control over their concentration;

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  • both high and low mood swings decrease; overall mood feels more stable;

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  • angry outbursts become less frequent and less extreme;

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  • patients report feeling less disorganized and better able to develop plans to complete tasks;

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  • patients report greater ability to tolerate stress;

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  • impulsivity decreases; become less likely to interrupt others and feel their communication skills improve.

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    (Remember, these changes are reported by patients who do not know whether they are receiving real medication or placebo, so they reflect REAL benefits of medication above and beyond the "placebo effect".)

    DOSAGES

    A very important issue in the use of medication for children and adults is arriving at the best dose for the individual. Dr. Wender reports that the majority of the adults with ADHD that he has studied and treated require a 10-15 mg dose of methylphenidate every 2-3 hours for a total of 40-90 mg. per day. In general, he has found that the sustained release version of methylphenidate does not control symptoms as well for many adult patients. Dr. Wender also advises that pulse and blood pressure should be carefully monitored in all adults who take stimulant medications, which would be an important issue to discuss with your physician.

    For adults who are treated with Pemoline, doses range from 75 to 150 mg/day, and the medication is generally administered once a day. (This one dose per day administration is an advantage over the multiple doses that may be required for adults taking methylphenidate). As with children, however, an important disadvantage- advantage of Pemoline is the possible adverse effect it can have on liver functioning (see Volume 10 of ADHD RESEARCH UPDATE.) For this reason, ongoing monitoring of liver functioning is essential.

    Dr. Wender has also investigated several other medications for treating ADHD in adults, although he indicates that these results are much more preliminary. Preliminary results suggest that Bupropion and selegilene may also be effective treatments for many adults with ADHD/ADD. Additional research on the efficacy of these medications, as well as several others, is ongoing and I will include results of these studies in ADHD RESEARCH UPDATE as they become available Tricyclic antidepressants- ants, in contrast, have not been found by Dr. Wender to be useful even though they are known to have documented efficacy in children.

    There are several other important points made in this excellent review article. As with children, there is really no way to predict in advance which will be the most effective medication for an individual or what will be the most effective dose. Some patients will do better on one type of medication while others will derive greater benefit from another. It is thus important to carefully and systematically monitor an adults response to the initial medication and dose prescribed. Information in this regard can be collected from the patient him or herself as well as from significant others who are in a good position to monitor and observe the patient's behavior. If an initial medication is not providing the full benefits that are hoped for, trying another type of medication may often yield better results.

    Dr. Wender also emphasizes the importance of ongoing education for patients with adult ADHD so that individuals can better understand how ADHD has effected, and may continue to effect, their develop- development. He stresses that psychological treatment should be com- bined with pharmacological treatment, and that medication by itself will rarely if ever be a sufficient form of intervention.
     

    * WHAT DO TEACHERS KNOW ABOUT ADHD? *

    Parents are often frustrated by what they perceive as a lack of knowledge and understanding of ADHD that is displayed by their child's teacher. A study that was published in the April 1998 issue of the Journal of Developmental Behavioral Pediatrics (pages 94-100) presents some interesting pilot data about what the knowledge base among teachers may be.

    The results of this study can not be generalized because only 44 teachers from a single school participated. Nonetheless, it is interesting to compare what was learned here with what the situation may be in your area.

    The authors report that prior to providing teachers with an in-service workshop on ADHD, 41% believe that ADHD could be caused by poor parenting, and an equal percentage believed that sugar or food additives caused ADHD. (Note that the prevailing view in the mental health profession is that ADHD is NOT caused by poor parenting and that reactions to sugar/food additives account for only a very small percentage of cases.) Almost 2/3s of teachers believed that medication should be used only as a last resort. (There is more disagreement about this issue within the profession but many practitioners do certainly not regard medication as the treatment of last resort.)

    An especially concerning finding was that over 60% of the teachers had never had any contact whatsoever with the physician who was prescribing medication to their student(s). This means, of course, that the doctor was receiving no direct feedback from the teacher about how the medication was effecting the child, what symptoms were and were not being helped, and what the effect of different doses seemed to be. In the absence of getting systematic feedback from the teacher, the likelihood of the child obtaining the maximum, possible benefit from medication is substantially reduced and it is really a shame that there continues to be so little effective monitoring of children's response to medication.

    What was encouraging about this study was how effective providing teachers with appropriate information about ADHD could be in changing some of their erroneous beliefs. In this study, teachers were presented with a curriculum on ADHD that was developed by ChADD , the national support group for children and adults with attention deficit disorder. At the conclusion of this curriculum, only 7% of teachers continued to believe that ADHD was caused by poor parenting, 5% still believed that food additives were the primary culprit, and 34% still felt that medication should only be used as a last resort. It is also interesting to note that teachers who participated in the educational meetings reported that they experienced significantly   less stress from their students with ADHD after learning more about ADHD and effective ways to help students with this condition.

    I think this study provides good initial evidence for how knowledge about ADHD among teachers may continue to be very suspect, which is quite unfortunate as it can make things much more difficult for children and parents. The absence of cooperation between teachers and physicians is also concerning. On the positive side, the results also suggest that many teachers are open to changing their beliefs when provided with new information. Perhaps working to organize an in-service workshop for teachers at your child's school could be a helpful and important thing to do.
     

    * SELF PERCEPTIONS AND SOCIAL RELATIONS OF BOYS WITH ADHD *

    As has been discussed in several prior issues of ADHD RESEARCH UPDATE, peer relations are often an area of difficulty for child   with ADHD. An article that appeared in the September, 1997 issue of the Journal of Clinical Child Psychology (pages 256-265) presents some interesting new information on this important issue.

    The authors of this study were intrigued by the fact that many children with ADHD seem to offer inflated (i.e. overstated) accounts of their own competence, and believed that such exaggerated self appraisals may serve a self-protective function for many children. This is the hypothesis that they wanted to test.

    This was tested by examining the effects of positive feedback on the self-perceptions and social interactions of boys with and without ADHD. Eight to 11 year old boys were participated in two unstructured, cooperative tasks with a same age peer whom they did not know. After the first interaction, half of the boys were given feedback that they believed was from their partner about how good a job they had done on the task and how much their partner liked them. This feedback was actually made up and had nothing to do with the other child's opinions.

    After the first task - but before receiving the bogus feedback - boys with ADHD reported an overly positive view of how much their partner actually liked them. In other words, they believed that their partner liked them more than their partner actually did.

    After received the bogus positive feedback, an interesting change occurred: boys with ADHD who received the feedback actually showed a decrease in their self-perceptions. That is, they now reported that their partner liked them less well than they did before, and the perceptions they now reported were actually more accurate. For boys without ADHD, receiving the positive feedback had the opposite and more expected effect in that their self-perceptions actually increased.

    The authors interpret these results as supporting their hypothesis that children with ADHD often provide inflated self-perceptions to counter their feelings of inadequacy. They believed that what was going on in their study is that when the boys with ADHD were given the positive feedback, they were able to relax their defensive post posture and provide more realistic self-assessments. In other words, because the positive feedback helped them to feel better about themselves, they no longer had the same need to describe themselves in unrealistically positive ways.

    This is an interesting and important finding that highlights the importance of findings ways to provide your child with positive feedback and praise. Although certainly not all children with ADHD may harbor inflated self-perceptions to ward off feelings of in adequacy, it is certainly easy to understand how tempting this may be for a child who is the recipient of negative feedback and criticism both at school and at home for most of the day.

    Something that is often helpful for parents that I work with is the reminder to try and catch their child "being good" at least 5 times each day and to be sure to point this out to their child. Positive feedback and praise from parents - when it is deserved - is an important basis for developing positive feelings about self that can reduce the need to latch on to overly positive and unrealistic views.

    An interesting and informative exercise to do is to keep track of the ratio of positive to negative statements that you make to your child each day. Many parents I have worked with are surprised at just how weighted towards the negative side their communication with their child turns out to be. This is easy to fall in to be- cause children with ADHD often behave in ways that elicit such negative feedback from parents, teachers, and others. That is why it can be so important to really make a deliberate effort each day to notice positive things to focus on and to convey your appreciation of these things to your child. The results of this study suggest that this approach can actually result in the child becoming more open to criticism and less defensive in how he or she reacts and relates to you and to others.
     

    * DOES LATE AFTERNOON RITALIN CAUSE INSOMNIA? *

    Parents and physicians are often reluctant to have children take a 3rd dose of stimulant medication after school because of concerns about the adverse effect this can have on the child's sleep. In many situations, a 3rd dose may seem necessary to help the child get through homework and to reduce behavioral difficulties as well. Nonetheless, this often not provided because of the concerns noted above. This concern is an important one, particularly because recent studies suggest that children with ADHD may be more prone to sleep difficulties, and, that sleep difficulties may exacerbate the symptoms for many such children (see Volumes 8 and 9 of ADHD RESEARCH UPDATE for reviews of recent studies on this topic.) A study published several years ago in the journal Pediatrics (August, 1995; pages 320-325) suggests that this concern - namely, that methylphenidate (i.e. the generic name for Ritalin) administered in the late afternoon will adversely affect a child's sleep - may be unfounded. In this study, 12 children with ADHD received a 4 PM dose of either 15 mg MPH, 10 mg MPH, or placebo in a randomized order for 12 consecutive days. Children in this study were inpatients at a child psychiatric hospital which allowed the researchers to monitor their sleep very carefully. Ratings of the children's behavior from the 4 PM dose through bedtime were also carefully recorded.

    Results indicated that MPH, in either the 10 or 15 mg doses, yielded marked improvements in children's behavior compared to placebo. In regards to the effect on children's sleep, no change in sleep   latencies (i.e. how long it took the children to fall asleep) were recorded. On the 10 mg dose of MPH, children were rated as less tired upon awakening compared to either the 15 mg dose or the placebo.

    This study's findings show that children with ADHD derive substantial symptom reduction from medication administered in the late afternoon, without there necessarily being an adverse effect on their sleep. Although the sample size is small, and the study should be repeated, there does not seem to be any a priori reason for an afternoon dose to be ruled out because it will ruin a child's sleep.

    I have had many parents tell me that their physician was unwilling to prescribe medication for after school hours because of this very concern. This can be unfortunate, because without medication, some children are just very difficult to manage at home and getting homework done in any reasonable way can seem almost impossible.

    Please note that what can not be concluded from a study like this is that your child will also tolerate afternoon medication well and that it will not effect his or her sleep. As has been emphasized repeatedly in prior issues of ADHD RESEARCH UPDATE, children's response to medication - including how a late afternoon dose may affect their sleep - is highly individualistic. A study like this one only suggests that it is unlikely that your child would have their sleep disrupted, not that it can not possibly happen.

    What guidelines, then, should be used to decide whether a child who is receiving medication should receive a dose in the later afternoon? First, I would want to know whether the problems with behavior and/or getting work done are severe enough to possibly warrant this. If a child is doing reasonably well in the afternoon without medication, then there may certainly be no clear reason to administer it. Second, I would want to know whether appropriate, behavioral strategies to deal with problems caused by a child's symptoms have been implemented without a sufficient level of success. Finally, it would be important to carefully monitor how a late afternoon dose affected this child's sleep - some children may really have their sleep affected in an adverse way even though this may be uncommon among children overall. If these questions are all addressed in a thoughtful and deliberate manner, than the odds that you are making the best choice for your own child will certainly be enhanced.
     

    * WHAT IS CONDUCT DISORDER? *

    In Volume 5 of ADHD RESEARCH UPDATE a discussion, I presented as overview of Oppositional Defiant Disorder (ODD), a behavioral disorder that children with ADHD are at increased risk for developing eloping. In this issue, I would like to present a similar over view of Conduct Disorder (CD), which is a more severe type of behavioral disorder that is also unfortunately more likely to develop in children with ADHD.

    According to DSM-IV, the publication of the American Psychiatric Association that provides current diagnostic criteria for all recognized psychiatric disorders, the essential feature of CD is "...a repetitive and persistent pattern of behavior in which the basic rights of others or age-appropriate social norms or rules are violated." These behaviors fall into 4 main groupings:
     

  • Aggressive behavior that causes or threatens to cause harm;

  • Examples: initiating fights; cruelty to people or animals;
     

  • Non-aggressive conduct that causes property loss or damage;

  • Examples: fire setting with intent to cause damage; deliberate destruction of property;
     

  • Deceitfulness or theft;

  • Examples: shoplifting; breaking into someone's house; frequent lying to obtain goods or avoid obligations;
     

  • Serious violation of rules;

  • Examples: truancy from school; running away from home; staying out at night prior to age 13;

    For the diagnosis of CD to be correctly assigned, at least 3 of the specific symptoms must have occurred during the prior 12 months, with at least one criterion present in the last 6 months. In addition, the disturbance in behavior must clearly result in clinically significantly   impairment in the child or teen's social, academic, or occupational   functioning. These criterion are intended to assure that the diagnosis is not assigned for an isolated antisocial act, but is instead reserved for youth who show a pattern of antisocial behavior over a significant period of time.
     

    Associated Features

    In addition to these core diagnostic criteria, individuals with CD often display a number of associated features as well. They often have little empathy or concern for the feelings and wishes of others; they are prone to often misperceive other's intentions towards them as being hostile which can lead them to overreact in a retaliatory, aggressive manner; guilt and remorse over clear misdeeds are often absent, other than feeling badly about having been caught; poor frustration tolerance and irritability are often present, and self esteem is often poor even though an image of "toughness" is often presented.

    CD is often also associated with the early onset of sexual behavior, substance use and abuse, excessive risk taking, and school suspension. Self-destructive behavior, including suicide, also occur at higher than expected rates. Not surprisingly, school suspensions, dropping out, and poor achievement are also quite common in individuals with CD.

    NOTE: It is important to recognize that the explicit symptoms of CD do not really share any overlap with diagnostic criteria for ADHD (see ). These two disorders certainly share many of the "associated features", but the actually symptoms that are used to make the diagnosis for each condition are really quite distinct. This is why if a child with ADHD is also displaying the types of behaviors that may warrant a CD diagnosis, it is important not to attribute the antisocial behavior to just another facet of the child's ADHD. The danger in doing this is that the child may not receive the necessary and appropriate treatment as a result.
     

    Subtypes of Conduct Disorder

    Two different types of CD are currently recognized. The Childhood- Onset Type is defined by the onset of at least on symptom of CD prior to age 10. Thus, even though a child may not meet full diagnostic criteria before age 10, if these criteria are met when the child is 12, and at least one symptom was present (e.g. running away) before 10, the Childhood-Onset Type would apply. Almost all children who meet criteria for childhood-onset CD would have previously   been diagnosed with Oppositional Defiant Disorder.

    The second subtype of CD is called the Adolescent-Onset Type. This type is applicable to individuals who current meet the diagnosis for CD but who showed no symptoms of CD prior to age 10. Individuals with adolescent-onset CD are less likely to display aggressive behavior and are more likely to have decent peer relationships. Of utmost importance is that adolescent-onset CD less likely to persist into adulthood.

    Although CD may occur in children as young as 5-6, it's onset is usually in late childhood or early adolescence. The course of CD is variable: in a majority of individuals, the disorder remits by adulthood. Nonetheless, a substantial percentage continue to display sufficient antisocial behaviors into adulthood to warrant the diagnosis of antisocial personality disorder as young adults. This is most likely to be true as noted above, for individuals whose CD begins early in life and is marked by aggressive behavior.
     

    What is the association between ADHD and CD?

    Data collected in numerous studies indicates that about 50% of children with ADHD will also develop ODD (i.e. Oppositional Defiant Disorder) or CD at some point during their development. An inter-   finding has been that although "pure" ADHD (that is, ADHD without either ODD or CD) is quite common in children, the reverse is almost never that case. In other words, it appears that virtually all children under age 12 who meet criteria for ODD or CD will also be diagnosed with ADHD. In these cases, it appears that the impulsivity and over activity that is characteristic of ADHD children, and the ensuing difficulties this creates in parent- child, teacher-child, and peer relationships, increases the risk for the kind of conflictual interactions that promote the develop   of these other disruptive behavior disorders.



    THIS IS WHY IT IS SO IMPORTANT THAT PARENTS LEARN ABOUT THE KINDS OF SPECIALIZED BEHAVIOR MANAGEMENT STRATEGIES THAT ARE OFTEN HELPFUL AND NECESSARY FOR CHILDREN WITH ADHD.
    Probably the most important thing a parent can do to help promote their child's long term success is to make sure that the proper steps are taken to prevent the development of these more severe behavior disorders that often develop in response to the problems that primary ADHD symptoms can cause.

    Here's why. The long term outcomes of children with pure ADHD and ADHD/CD are very different. For example, in one study in which samples that followed two samples of ADHD children - one with high levels of aggressive behavior and the other without - there were no cases of drug or alcohol abuse at age 14 in the ADHD only group, while for the ADHD aggressive group, over 30% had engaged in substance abuse. In a similar study using different samples of children, approximately 1/3 of ADHD/CD boys had committed multiple crimes as teenagers compared to fewer than 4% of boys who had been diagnosed with ADHD alone.
     

    Treatment

    I'll try to cover treatment of CD and ADHD/CD in a subsequent issue of ADHD RESEARCH UPDATE. For now, it is important to note that in several double-blind, placebo-controlled studies, children with ADHD/CD show an equally robust response to stimulant medication as do children with ADHD alone. In addition, there is some evidence that not only primary ADHD symptoms are reduced, but that antisocial behaviors themselves such as aggression and stealing are also reduced. It is widely believed that children with ADHD/CD as well as children with CD alone clearly require more intensive behavioral and psychosocial interventions than children with ADHD alone, but the research data that exists on this question is somewhat limited at this time. Studies are currently underway that promise to begin providing answers to these important questions, and I will certainly include them in the newsletter as they begin to be published.
     

    - READER QUESTIONS -

    "My child was recently diagnosed with ADHD. I'm reluctant to tell new teacher this because I'm concerned he will get labeled as a problem student. What do you recommend?"

    I've actually had this concern expressed by many of the parents I have worked with. It is certainly the case that there may be some teachers who would respond to learning that one of their students has ADHD by doing the kind of labeling in their own mind that this parent is concerned about. The teacher may expect certain behaviors from the student and not give the child the benefit of the doubt or be as open minded with this student as with others. As seen above, it is even possible that a teacher would erroneously believe that the child's ADHD has resulted from poor parenting, and thus have similar preconceptions about dealing with the child's parents. For these reasons, some parents are reluctant to share their child's diagnosis with the school. On the other hand, most students with ADHD really do need certain accommodations at school in order for them to maximize their success. Preferential seating, untimed tests, help with keeping track of assignments, etc. are just some examples of what may be required. Students with ADHD may be entitled to these types of accommodations as well as many others based on guidelines outlined in two federal laws. Unless the child's diagnosis is made known to the school, however, the extra assistance the child may need is less likely to be forthcoming as the child must be officially identified as having ADHD before the federal laws would apply. My own feeling on this issue is that if a teacher reacts negatively to learning about a child's diagnosis, and is unable or unwilling to modify their attitude and behavior towards the child, parents must take active steps to have their child removed from this teacher's class. I really think it is essential for a child's teacher and school to be aware of the child's diagnosis so that the appropriate steps to provide the child with the extra assistance that is necessary can be taken. Without this assistance, many children with ADHD are simply going to have a much more difficult time in the classroom. As time goes on, hopefully fewer and fewer teachers will engage in the negative labeling that parents are concerned about so that this will become less of an issue. "I'm trying to encourage good behavior in my child at school this year by promising him a reward on the weekend if he has a good week at school. After only 2 weeks, though, it is clear that this does not seem to be working. Any suggestions?" The main problem that may exist with the plan you are using is that having to be "good" for an entire week in order to earn a desired reward is simply too long a time period for most children with ADHD. It is just very hard for most children with ADHD to stay focused on long term goals, so this may not be providing the type of incentive you need. For behavioral plans to be effective for children with ADHD, much shorter time intervals between the behavior you are trying to encourage and the privilege they will earn are usually required. One "typical" program might provide a reward midway through the school day for good behavior in the morning; the opportunity to earn an extra privilege at home in the afternoon for good behavior during the second part of the school day; and, a somewhat larger reward that can be earned on the weekend for an overall good per- performance during the week. With this type of schedule, the child is consistently working to attain more short terms goals and rewards, and this is also tied in to a longer term goal as well. In addition to providing this type of short term incentive, there are several other things that are important to keep in mind when developing this type of behavior plan for a child with ADHD. These include:

     
     
  • clearly defining the behaviors you expect of the child - it is essential that the child fully understand what he or she has to do in order to earn their desired reward;

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  • focusing on only a few things at a time - I never try to target more than 2 or 3 behaviors at any one time;

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  • providing the child with frequent reminders of what is expected of them and what rewards they are working to earn;

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  • letting the child take an active role in helping to design the program - i.e. getting the child's input on what they need to work on, what rewards they would like to earn, etc.

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  • changing the incentives frequently so that the child does not get bored with the program;

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  • setting the program up so that the child has an excellent chance to be successful with it early on - you can always make the required standards to earn rewards more stringent as things progress, but if the child does not experience some early success, he or she may quickly become discouraged and lose interest.

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    Try incorporating some of these suggestions into the behavior plan you are trying and you may find that it is more successful. If things continue to be a struggle, consulting with an experienced child mental health professional to help develop a good behavior plan is strongly recommended.

    copyright 1998 ADHD RESEARCH UPDATE.

    Please feel free to share this information with others who may benefit from it. If they would like to receive this newsletter on a regular basis, however, please suggest that they contact me about subscribing at addhelp@mindspring.com. Thank you.
     

    David Rabiner, PhD
    Licensed Psychologist